Civona

All skin types.

Apply 1-2 pea size AM as step 2. Can mix with other serums. Do not rinse off.

Active Vitamin C Complex

5% Ascorbyl Tetraisopalmitate - Liquid Vitamin C - is one of the most effective and beneficial cosmetic antioxidants available today. The modified vitamin is released as pure C internally. It is invaluable, stable antioxidant as it works to protect against UV induced cell damage and lipid peroxidation, two of the strongest contributors to the aging process

Australian summers are amongst the hottest in the world and the more we protect and nourish our skin from the sun, the better it is for our future. One important action of Vitamin C is that it adds extra protection to the skin on a cellular level by increasing the cell survival rate in the epidermis when exposed to UV rays. Exposure to UV rays is the highest contributor of premature aging and potential skin disorders.

Another unique quality of our cosmetic Vitamin C oil-soluble liquid is that it prevents lipid peroxidation. Lipid peroxidation results from free radical damage and also contributes to cell damage and premature aging. Our lipophilic Vitamin C liquid makes it a unique product which is readily absorbed into the skin providing added protection and nourishment

Benefits:

• Being lipophilic it has superior absorption qualities

• Exhibits a lightening effect on the skin and may help reduce the appearance of pigmentation

• Potent anti-oxidant properties protect against DNA cell damage induced by UV exposure

• Prevents & repairs lipid peroxidation to aid surface plumping & fine lines

• Protects the skin against exogenous ageing

• Promotes collagen synthesis and collagen protection restore & maintain skin youth

7.5% Terminalia Ferdinandiana (Kakadu Plum)

It is vital to maintain the delicate balance of nature by harnessing phyto-actives without damaging the plant’s bio-matrix. Outdated extraction methods (maceration/percolation/powders) place a plant under extreme stress, compromising the integrity of the natural molecules, breaking their bonds and rendering them an inactive extract of decomposed plant matter. CELLULAR EXTRACTION mimics the cell environment and rapidly transfers the full range of naturally occurring water-soluble phytonutrients into a medium that maintains the stability and integrity of the phyto-compounds, as they exist in nature in their synergistic relationships

• Water soluble , extracted from the Kakadu Plum, the richest source of vitamin C (Superfruit)

• Free radical scavenger due to high Vitamin C content and polyphenol contents

• Induces vitamin C transporter (SVCT-1) synthesis on skin cells

• Stimulates pro-collagen I and hyaluronic acid synthesis

• Reduces the appearance of wrinkles

• Fights and protects the skin against oxidative stress

• Boosts skin radiance and luminosity

• Improves skin tone evenness with an overall brightening effect

Active Peptides 5%

Tetrapeptide 30 – Biomimetic (skin identical) Amino acid sequence Proline –Lysine – Glutamic Acid – Lysine

• Active on all kinds of skin types

• Visibly diminishes hyperchromatic spots

• Brightens skin and improves the evenness of skin tone

• Reduces acne lesions

• Alleviates melasma on ethnic skin

• Provides a significant anti-inflammatory effect

• Safely inhibits the pigmentation process without toxicity or rebound effect

SNAP 8 - Acetyl Octapeptide-3 Amino- peptide that blocks transmitter signals from facial muscles to the skin

• SNAP 8 is a mimic of the N-terminal end of SNAP 25. It competes with SNAP 25 for a position in the SNARE (SNAp Receptor) complex, an essential process for neurotransmitter delivery.

• By modulating its formation & destabilising this complex the release of neurotransmitters is inefficient, weakening muscle contraction

• Reduces repeated facial movements preventing the formation of lines & wrinkles

• Maintains youthful structural fibres of collagen, elastin & packing of the lipid matrix

• Maximum wrinkle reduction value found with usage of 10% SNAP 8 was 63.13%

• 34.98% wrinkle depth reduction after 28 days with 10% SNAP (applied twice daily)

Matrixyl Synthe-6 - Palmitoyl Tripeptide-38

• Derived from the tripeptide KMK naturally found in collagen VI and laminins (a protein network foundation of the extracellular matrix. These glycoproteins are an integral part of the structural scaffolding, influencing cell differentiation, migration, and adhesion. Capable of binding to cells, which helps anchor organized tissue cells to the membrane & is vital for the maintenance and survival of healthy tissue

• Stimulates the synthesis of 6 major constituents of the skin matrix and dermal-epidermal junction (collagen I, III, IV, fibronectin, hyaluronic acid and laminin 5)

• Matrixyl Synthe-6 evens out skin and smoothes wrinkles from the inside by rebuilding the skin where it is needed, particularly on the forehead and crow's feet

• It’s primary function is to plump wrinkles & restore a youthful voluminous look

• 62% reduction in wrinkle depth after 28 days with 2% Matrixyl Synthe 6

Palmitoyl Oligopeptide - studies have proven that this ingredient can refuel Collagen production by 350% & Hyaluronic Acid production by 146% - amino acids Glycine, Glutamine, Proline and Arginine make up this particular form of Oligopeptide

• Mimics skins natural trigger for accelerated collagen synthesis

• Reduces depth of wrinkles & skin roughness

• Deeply penetrating properties that encourage skins natural healthy function & elasticity

• increase in Hyaluronic Acid provides plumpness from within , combating lines & deep wrinkles

• Works synergistically with Palmitoyl Tetrapeptide-7 promoting overall skin healing & regeneration

Palmitoyl Tetrapeptide-7 - Compound which combines several chains of amino acids to reduce skin inflammation and related skin damage

• Stimulates regeneration of collagen fibres in the dermis by acting as a cellular messenger

• Increases hyaluronic acid helping to tighten skin by attracting moisture to the epidermis

• Skin penetration enhancer

• Decreases inflammation by suppressing Interleukin (created in response to damage) which leads to cellular deterioration

• Accelerates healing by relieving chemical pressure on the skin

• Induces natural collagen production for skin healing and rejuvenation

• Symptoms of rosacea maybe alleviated

• Reduce the appearance of uneven skin tones

ChroNOline™ (Caprooyl Tetrapeptide-3) - Biomimetic peptide derived from a growth factor

• Boosts the production of key components of the DEJ (collagen VII, laminin-5 and fibronectin) reinforcing healthy skin structure, volume & definition

• Helps accelerate the reduction of the appearance of fine lines and wrinkles after only 28 days for younger skin appearance

• Activates skin repair

Beta-White: TM Advanced Lightening Agent Biomimetic Peptide TGF-B / Transforming Growth Factor-Beta

• First ingredient with a unique inhibitory action on MITF (Microphthalmia – associated transcription factor) cellular pathway

• Reducing MITF activity as well as Tyrosinase aids B-White to reduce Melanin

• B-White binds to the TGF-B receptor on Melanocytes. This specific binding introduces an intracellular cascade leading to reduction in MITF activity

• B-White has the ability to modulate constitutive (natural skin colour) & facultative (UV induced) pigment

• Traditional lightening methods address Tyrosinase inhibition only

• Liposomal encapsulation stabilises & delivers Oligopeptide-68 (Biomimetic Peptide TGF-B)

Acetyl Tetrapeptide-2 Biomimetic Peptide (EGCG - Epigallocatechin-3-Gallate)

• Active constituent of Green Tea - Initiates NRF-2, the master switch for anti-oxidant signalling

• Protects ECM degradation & modulates inflammation

• Shields DNA, membrane integrity & skin structure

• Reduces oxidative stress & lipid peroxidation

• Inhibits melanogenesis & glycation

Palmitoyl Tripeptide-8: Lipopeptide derived from a neuromediator

• Prevents and reverses signs of neurogenic inflammation

• Calms and soothes irritated skin and

• Helps to maintain and restore a normal skin sensitivity threshold

• Restores natural skin defence mechanism & aids barrier repair

L-Glutathione – Master anti-oxidant, playing an important role in preventing oxidative damage to skin & its many biological functions by binding to oxidative compounds that damage cell membranes, DNA, and energy production. A tripeptide, consisting of a small protein composed of three amino acids: Cysteine – Glycine - Glutamic acid (or glutamate)

• Protects mitochondria (power plant of the cell) to reduce apoptosis, final death message to a cell damaged beyond repair. Guarding cells vital energy source

• Inhibits NF-κ, the master controller of inflammation, blocking the production of most inflammatory cytokines that keep you in a state of constant inflammation, reducing acne, psoriasis, wrinkles, melasma & all age related skin conditions

• Neutralizes a wide range of oxidants, including superoxide, nitric oxide, carbon radicals, hydroperoxides, peroxynitrites, and lipid peroxides.

• Low levels of L-Glutathione trigger a cascade that leads to cell injury and death, which accelerates ageing

• Activates and protects immune cells to strengthen the immunologic function

• Associated with skin lightening due its anti-melanogenic properties inhibiting the activity of tyrosinase enzyme in skin cells

• Utilises different mechanisms to employ action as a skin whitening agent at various levels of melanogenesis

• Distorts melanogenesis from the darker eumelanin to the lighter phaeomelanin

• Noted importance of potent free radical scavenging to negate ROS & heightened response of inflammatory instigated melanin

L-Arginine – Research indicates it’s importance in collagen synthesis by forming L-proline & protein fusion that speed the regenerative processes of the skin aiding wound recovery. Can enhance release of human growth hormone helping to slow the ageing process

Magnesium Aspartate, Zinc Gluconate & Copper Gluconate – Powerhouse multi-mineral blend of elements helps to maintain healthy skin function & instigate cellular regeneration. Improves oxygenation of the skin cells, heightens immune responses reducing stress. Enhances & brightens skin tone, restoring optimal skin vitality via immediate availability of oxygen to the skin, stimulating tissue metabolism. Protection of fibers of the extracellular matrix & structural proteins of fibroblasts. Boosts the activity of GAP junctions (intercellular channels that allow the passage of water, ions, and small molecules. They are involved in quick, short-range messaging between cells) & increase the inter-keratinocyte dialogue

• GLYCATION begins from the age of 20 & increases naturally every year by 10% each year It is a natural & spontaneous reaction between a protein and a sugar that causes stiffening of the protein that is losing its functionality KEY SKIN TARGETS : dermal proteins (collagen and elastin) and intra-cellular proteins. VISIBLE SIGNS: Loss of elasticity, firmness & appearance of wrinkles

• LOSS OF THREE-DIMENSIONAL SKIN COMMUNICATION WITH AGE In the epidermis, the inter-keratinocyte exchanges via the GAP ( junctions reduce causing a decrease in epidermal homeostasis and keratinocyte differentiation. This results in skin dryness, wrinkles & weakened photoprotective effect

• Magnesium Aspartate – Natural anti-stress Involved in production of energy, DNA and proteins. Increases exchanges between the cells. Encourages protein synthesis and phosphates transfer

• Copper Gluconate - Maintains skin integrity. Detoxifying. Encourages synthesis of ATP, keratin and collagen

• Zinc Gluconate - Antioxidant (coenzyme of SOD – Super Oxide Dismutase) Essential for DNA & protein rejuvenation plays a role in the synthesis of DNA. It helps combat aging by stimulating reversal of damaged collagen matrix

Lactobacillus Ferment Lysate (Pre|Probiotic) – Cutting edge technology deploys antimicrobial peptide (Bacteriocin)

• Advanced oligosaccharide fructans are supplemented into Lactobacillus acidophilus growth media providing potent antibacterial activity

• Lysozyme addition ensures release of filtered pure pre|probiotics

• Reduces erythema, itching & flaking to aid reversal of damaged skin

• Balances healthy microbiome for optimal hydration & recalibrated age resistance

Hydrolysed Marine Collagen - Has a similar amino acid content to the collagen contained in skin These are our skins fundamental building blocks for structural support (collagen, elastin) inhibiting wrinkle formation & maintaining youthful volume

Hyaluronic Acid - Mid – High Molecular Weight

• Natural Moisturising Factor that attracts + binds up to 1000 X its own weight in moisture

• Plumps surface tissue to alleviate dry, thinning skin

• Assists wound healing + repairs barrier function

• Inhibits Trans Epidermal Water Loss– essential for atopic skins

Hyaluronic Acid - Low Molecular Weight

• Trials indicate a reduction in immune-derived inflammation, improving scaling, erythema & pruritus. Effective Seborrheic Dermatitis Rx

• Biological activity triggers built-in immune defence mechanisms whilst inducing anti-bacterial responses effectively healing skins epithelium

• Penetrates effectively to rebuild + plump deeper layers firming the skins surface

• Replenishes the hydration factors diminished with ageing + sun damage to mimic youthful levels

Magnesium Ascorbyl Phosphate - Vitamin C

• Water Soluble, non-irritating, stable derivative of Vitamin C

• Enzymatically converted into L-ascorbic within the skin

• Boosts collagen synthesis

• Suppresses melanin production, inhibiting further pigmentation reducing existing uneven pigment

• Ideal for sensitive skin types

• Protects the skin against oxidative stress caused by sun, pollution & heat

• Boosts radiance and reduces signs of ageing

Mangosteen Extract – Potent anti-oxidant rich in Vitamin C with anti-inflammatory, anti-bacterial & anti-tumour properties. Efficient vasodilator that accelerates wound healing by assisting recession of blood back into the body

Phyto Actives | Anti-Oxidants | Anti-Inflammatories: Alpha Bisabilol (Pure Chamomile Extract) D-Alpha Tocopherol (Pure Vitamin E) Apple Fruit Extract, Beta-Glucan. With an abundance of flavonoids (phytonutrients or plant chemicals) that provide remedial benefits through cell signalling pathways and antioxidant effects, these botanical wound healing agents function as anti-oxidants and protect the skin cells from oxidation